Figure 2

T-cell receptor signaling. This network diagram outlines the overlap of genes shared between critical TCR pathways including PD-1, CD3 phosphorylation and ZAP70 translocation. Edges connect SNV enriched genes to the pathways they are involved in, and show all genes that are involved in all three pathways. HLA-DRB1, HLA-DRA and HLA-DRB5 are shared by all three of these pathways.