Table 1 Clinico-pathological characteristics of sequencing cohorts.
Clinicopathological characteristics | Exome (N = 25) | Hotspot (N = 17) | |
|---|---|---|---|
Gender | Male | 14 | 11 |
Female | 11 | 6 | |
Age (Median) | 66 (IQR 18 years) | 64 (IQR 16 years) | |
Resection | Hepatic and bile duct | 19 | 14 |
Bile duct only (Type II) | 6 | 3 | |
TNM (AJCC 2017) | I | 1 | 1 |
II | 13 | 6 | |
IIIA | 0 | 1 | |
IIIB | 0 | 0 | |
IIIC | 11 | 8 | |
IVA | 0 | 1 | |
IVB | 0 | 0 | |
Radial margin | R1 | 8 | 3 |
R0 | 17 | 14 | |
Circumferential margin | R1 | 13 | 10 |
R0 | 12 | 7 | |
Peri-neural invasion | Yes | 24 | 16 |
No | 1 | 1 | |
Vascular invasion | Yes | 15 | 9 |
No | 10 | 8 | |
Cell differentiation | Well | 4 | 1 |
Moderate | 15 | 10 | |
Poor | 6 | 6 | |
Precursor lesion | BiliN | 0 | 0 |
IPNB | 1 | 0 | |
None | 24 | 17 | |
Risk factor | PSC | – | – |
Caroli’s disease | – | – | |
Cholelithiasis/Choledocholiathiasis | 4 | 1 | |
Choledochal Cyst | – | – | |
Cirrhosis | – | – | |
Hemochromatosis | – | – | |
Chronic liver infection (HCV/HBV) | – | – | |
Inflammatory Bowel Disease | – | – | |
Chronic pancreatitis | – | – | |
Type II Diabetes | – | 1 | |
Non-alcoholic fatty liver disease | 1 | – | |
Obesity | 4 | – | |
Hypertension | 7 | 2 | |
Excess alcohol consumption | 1 | – | |
Cigarette smoking | 3 | 2 | |
