Table 2 Univariate and multivariate Cox regression models for OS in stage III patients.

From: Stage III deficient mismatch repair colon patients get greater benefit from earlier starting oxaliplatin-based chemotherapy regimen

Variable

Univariate analysis

Number

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

p

Sex

 Female

1

0.633

37

  

 Male

1.203 (0.563–2.572)

38

Age

1.077 (1.036–1.118)

 < 0.001

 75

1.048 (1.004–1.094)

0.030

Depth of tumor invasion (T)

 T1–T3

1

0.451

56

  

 T4

1.376 (0.600–3.156)

19

Positive lymph nodes (N)

 1–3

1

0.060

53

  

  ≥ 4

2.076 (0.969–4.445)

22

Location

 Proximal colon

1

0.923

48

  

 Distal colon

1.039 (0.476–2.271)

27

Operation

 Open surgery

1

0.089

51

  

 Laparoscopic

0.430 (0.163–1.136)

24

Positive lymph nodes

1.165 (1.058–1.284)

0.002

 75

1.167 (1.048–1.300)

0.005

Histologic grade

 Low grade (1/2)

1

27

1

 High grade (3/4)

2.870 (1.136–7.252)

0.026

37

2.908 (1.115–7.585)

0.029

 Special type

1.292 (0.323–5.176)

0.717

11

0.967 (0.218–4.298)

0.965

Chemotherapy regimens

 Surgery alone

1

 

33

1

 

 Oxaliplatin early

0.082 (0.011–0.613)

0.015

16

0.106 (0.013–0.857)

0.035

 Oxaliplatin later

0.594 (0.220–1.603)

0.304

12

0.584 (0.181–1.888)

0.369

 Other regimens

0.338 (0.099–1.151)

0.083

14

0.758 (0.188–3.059)

0.697

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