Table 2 Frequency of mutations associated with resistance to different anti-malarial drugs, from Bijagós P. falciparum isolates (n = 15, sample collection in 2018) and P. falciparum isolates from West Africa (Total n = 218, Ivory Coast n = 70—sample collection in 2013, The Gambia n = 148—sample collection in 2008 and 2014).
Gene | Position | Mut | Ref allele | Alt allele | n/N mutation Bijagós | n/N mutation W. Africa | % Mut in Bijagós | % Mut in W. Africa | P value (X2) |
|---|---|---|---|---|---|---|---|---|---|
pfcrt | 403,625 | K76T | A | C | 4/14 | 112/218 | 28.6 | 51.4 | 0.098 |
pfdhfr | 748,239 | N51I | A | T | 14/14 | 167/218 | 100 | 76.6 | 0.040 |
pfdhfr | 748,262 | C59R | T | C | 13/14 | 169/218 | 92.9 | 77.5 | 0.158 |
pfdhfr | 748,410 | S108N | G | A | 14/14 | 176/218 | 100 | 81.1 | 0.070 |
pfdhps | 549,993 | K540E | A | G | 0/15 | 0/218 | 0 | 0 | - |
pfdhps | 549,685 | A437G | C | G | 9/15 | 162/218 | 60.0 | 74.3 | 0.225 |
pfdhps | 550,117 | A581G | C | G | 0/15 | 2/218 | 0 | 0.9 | 0.709 |
pfdhps | 549,681 | S436A | T | G/C | 3/15 | 64/218 | 20.0 | 29.4 | 0.439 |
pfmdr1 | 958,145 | N86Y | A | T | 1/13 | 34/218 | 7.7 | 15.6 | 0.440 |
pfmdr1 | 958,440 | Y184F | A | T | 7/13 | 131/218 | 53.8 | 60.1 | 0.656 |
pfmdr1 | 961,625 | D1246Y | G | T | 0/13 | 2/218 | 0 | 0.9 | 0.729 |
pfkelch13 | 1,725,626 | N458Y | T | A/C | 0/14 | 0/218 | 0 | 0 | - |
pfexo | 2,504,560 | E415G | A | G | 0/13 | 0/218 | 0 | 0 | - |
pfap2µ | 718,433 | S160N/T | G | A/C | 0/14 | 12/218 | 0 | 5.5 | 0.367 |
