Figure 8

The role of NM-TME classifier in immunotherapy. (A) Proportion of response to immunotherapy in different groups. (B) Proportion of MSI in different groups. (C–F) Comparison of the relative distribution of IPS across groups with high NM/low TME and low NM/high TME. Functional analysis in the NMlow/TMEhigh group (G) and responder of patients under immunotherapy (H) illustrated using Proteomaps. A little polygon represents a unique KEGG pathway. NM nucleotide metabolism, TME tumour microenvironment, MSI microsatellite instability, IPS immunophenoscore.