Table 2 Allelic and genotypic distribution of SLC11A1 gene polymorphisms.

From: Association of SLC11A1 polymorphisms with anthropometric and biochemical parameters describing Type 2 Diabetes Mellitus

Polymorphism

T2DM, n (%)

Control, n (%)

Genetic model

OR (95% CI)*

p value*

rs3731864 G/A

 GG

360 (90.0)

321 (80.3)

 

1 [reference]

–

 GA

37 (9.2)

73 (18.2)

Codominant 1

0.43 (0.28–0.66)

< 0.001

 AA

3 (0.8)

6 (1.5)

Codominant 2

0.46 (0.11–1.86)

0.278

 HWE

0.095

0.434

Dominant

0.43 (0.28–0.65)

< 0.001

Recessive

0.52 (0.13–2.08)

0.353

Over Dominant

0.43 (0.28–0.67)

< 0.001

 G

757 (94.6)

715 (89.4)

Allelic

1 [reference]

–

 A

43 (5.4)

85 (10.6)

Allelic

0.46 (0.31–0.68)

< 0.001

rs3731865 C/G

 CC

303 (75.8)

333 (83.3)

 

1 [reference]

–

 CG

95 (23.7)

65 (16.2)

Codominant 1

1.53 (1.07–2.19)

0.019

 GG

2 (0.5)

2 (0.5)

Codominant 2

1.13 (0.16–8.09)

0.901

 HWE

0.064

0.75

Dominant

1.52 (1.07–2.16)

0.020

Recessive

1.04 (0.15–7.43)

0.967

Over Dominant

1.53 (1.07–2.19)

0.019

 C

701 (87.6)

731 (91.4)

Allelic

1 [reference]

–

 G

99 (12.4)

69 (8.6)

Allelic

1.44 (1.03–2.00)

0.029

rs17235416 + TGTG/−TGTG

 + TGTG/+ TGTG

378 (94.5)

356 (89.0)

 

1 [reference]

 

 + TGTG/− TGTG

21 (5.2)

41 (10.2)

Codominant 1

0.48 (0.27–0.83)

0.009

 − TGTG/− TGTG

1 (0.3)

3 (0.8)

Codominant 2

0.33 (0.03–3.16)

0.334

 HWE

0.28

0.15

Dominant

0.47 (0.27–0.80)

0.006

Recessive

0.35 (0.04–3.34)

0.358

Over Dominant

0.48 (0.28–0.84)

0.010

 + TGTG

777 (97.1)

753 (94.1)

Allelic

1 [reference]

–

 − TGTG

23 (2.9)

47 (5.9)

Allelic

0.47 (0.28–0.79)

0.004

  1. T2DM Type 2 Diabetes Mellitus, n represents the numbers, CI confidence intervals, OR odds ratio, HWE Hardy–Weinberg equilibrium, BMI body mass index, *p-value and OR (95% CI), BMI-adjusted. Codominant 1 and Codominant 2 represent the heterozygous and homozygous codominant models, respectively. p < 0.05 were considered statistically significant, indicated in Bold.
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