Table 3 Incidence and relative risk of clinical outcomes by 1-year landmark analysis.

From: Impact of coronary artery revascularization on long-term outcome in hypertrophic cardiomyopathy patients: a nationwide population-based cohort study

 

HCM group

Non-HCM control group

 

Event/N

IR-per 1000 p-y

Event/N

IR-per 1000 p-y

Unadjusted

HR (95% CI)

P

*Adjusted

HR (95% CI)

P

PS-Matched

HR (95% CI)

P

All-cause death

0–1-year

34/431

82.9

106/1968

56.0

1.48 (1.00–2.17)

0.048

1.76 (1.17–2.65)

0.007

2.10 (1.15–3.81)

0.015

1-year–

45/326

37.3

171/1552

26.1

1.47 (1.06–2.05)

0.022

1.65 (1.17–2.32)

0.004

1.67 (1.06–2.66)

0.029

Cardiovascular death

0–1-year

20/431

48.8

66/1968

34.9

1.39 (0.84–2.30)

0.195

1.81 (1.06–3.08)

0.030

2.03 (0.95–4.33)

0.068

1-year–

25/326

20.7

53/1552

8.1

2.63 (1.63–4.24)

 < 0.001

2.81 (1.71–4.61)

 < 0.001

4.98 (2.03–12.22)

 < 0.001

Sudden cardiac death

0–1-year

6/431

14.7

20/1968

10.6

1.39 (0.56–3.45)

0.484

1.14 (0.44–3.00)

0.787

1.53 (0.43–5.43)

0.508

1-year–

16/326

13.3

34/1552

5.2

2.55 (1.40–4.62)

0.002

2.51 (1.34–4.71)

0.004

2.90 (1.12–7.47)

0.028

Ischemic stroke

0–1-year

11/431

27.3

25/1968

13.3

2.04 (1.01–4.15)

0.048

1.73 (0.81–3.73)

0.160

5.14 (1.13–23.45)

0.035

1-year–

20/326

16.9

40/1552

6.2

2.70 (1.57–4.62)

 < 0.001

2.53 (1.43–4.46)

0.001

4.47 (1.68–11.93)

0.003

Hospitalization due to heart failure

0–1-year

50/431

132.6

161/1968

89.2

1.47 (1.07–2.01)

0.018

1.22 (0.87–1.71)

0.247

1.36 (0.89–2.09)

0.160

1-year–

67/326

62.2

244/1552

39.9

1.56 (1.19–2.05)

0.001

1.57 (1.18–2.08)

0.002

1.46 (1.02–2.08)

0.039

Ventricular arrhythmia (VT/VF)

0–1-year

4/431

9.8

19/1968

10.1

0.97 (0.33–2.85)

0.955

0.52 (0.17–1.64)

0.266

0.61 (0.15–2.55)

0.498

1-year–

13 / 326

10.9

16/1552

2.5

4.31 (2.07–8.96)

 < 0.001

3.79 (1.75–8.23)

 < 0.001

3.63 (1.18–11.13)

0.024

Myocardial infarction

0–1-year

7/431

17.2

46/1968

24.5

0.70 (0.32–1.56)

0.384

0.91 (0.40–2.10)

0.829

1.03 (0.36–2.93)

0.957

1-year–

5/326

4.2

44/1552

6.8

0.59 (0.23–1.48)

0.256

0.53 (0.20–1.39)

0.196

0.59 (0.20–1.77)

0.347

Repeat revascularization

0–1-year

21/431

52.4

130/1968

70.9

0.74 (0.47–1.17)

0.199

0.79 (0.49–1.28)

0.338

0.68 (0.38–1.19)

0.177

1-year–

36/326

32.0

164/1552

27.0

1.15 (0.80–1.65)

0.449

1.06 (0.72–1.55)

0.773

0.92 (0.59–1.44)

0.718

  1. *Multivariable Cox regression model included age, sex, low income, revascularization due to acute MI, revascularization after coronary CT angiography, hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, previous stroke, and congestive heart failure.
  2. Abbreviations: CI, confidence interval; CT, computed tomography; HCM, hypertrophic cardiomyopathy; HR, hazard ratio; IR, incidence rate; MI, myocardial infarction; PS, propensity score; p-y-person-years; VF, ventricular fibrillation; VT, ventricular tachycardia.
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