Figure 2

Risk of hypoglycemia in patients receiving glucose-lowering drugs with eGFR < 50 mL/min/1.73 m2 stratified by eGFR using marginal Cox proportional hazards regression analysis while controlling for baseline covariates. All analyses were adjusted for patient age, sex, number of severe hypoglycemic events within the previous year, number of concurrent use of glucose-lowering drugs, use of insulin, Charlson Comorbidity Index, and HbA1C. eGFR, estimated glomerular filtration rate (estimated using the body surface area modified Cockcroft–Gault formula).