Table 2 Risk of hypoglycemia associated with inappropriate and appropriate dosing.

From: Hypoglycemia risk with inappropriate dosing of glucose-lowering drugs in patients with chronic kidney disease: a retrospective cohort study

Classification of hypoglycemia

Inappropriate dosing group

Appropriate dosing group

Unadjusted HR (95% CI)

Adjusteda HR (95% CI)

Events

Duration (person-month)

Incidence rate (events per 10,000 person-month)

Events

Duration (person-month)

Incidence rate (events per 10,000 person-month)

Composite of all

417

54,359

76.71

651

134,207

48.51

1.58 (1.36, 1.83)

1.52 (1.31, 1.78)

Severe

97

54,658

17.75

120

134,801

8.90

1.98 (1.51, 2.61)

1.87 (1.40, 2.49)

Moderate

62

54,735

11.33

94

134,861

6.97

1.62 (1.16, 2.26)

1.71 (1.20, 2.43)

Mild

280

54,563

51.32

450

134,472

33.46

1.53 (1.28, 1.83)

1.46 (1.21, 1.76)

  1. aAdjusted for patient age, sex, number of previous severe hypoglycemic events within the previous year, number of concurrent use of glucose-lowering drugs, use of insulin, use of sulfonylurea, Charlson Comorbidity Index, and HbA1C.
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