Figure 1
From: Green tea extract prevents CPT-11-induced diarrhea by regulating the gut microbiota
Effects of GTE on CPT-11-induced delayed diarrhea. Rats were administered CPT-11 or lactic acid buffer intravenously for 4 days, and HST or GTE was administered in combination (A). Body weight (B), 24-h food intake (C), and fecal water content (D) were measured. The water content in feces is shown as 100% of the mean value in the control group. The mRNA levels of IL-6 (E), IL-1β (F), and iNOS (G) in the colon were measured by real-time PCR. The levels of each gene were normalized using β-actin levels and are shown as 100% of the mean value in the control group (mean ± S.D., n = 5, *p < 0.05, **p < 0.01, *** p < 0.001 vs. Cont., †p < 0.05, †††p < 0.001 vs. CPT-11).
