Table 3 Associations between change in TC and risk of CHD and stroke subtypes.
From: Changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patients
TC level before T2D diagnosis (mg/dL) | Low (< 180 mg/dL) | Middle (180–240 mg/dL) | High (≥ 240 mg/dL) | ||||||
|---|---|---|---|---|---|---|---|---|---|
TC level after T2D diagnosis (mg/dL) | Low | Middle | High | Low | Middle | High | Low | Middle | High |
Number of subjects (N) | 3681 | 1815 | 148 | 4367 | 7663 | 1245 | 1093 | 2395 | 1415 |
CHD subtypes | |||||||||
Angina (I20) | |||||||||
Number of cases (n) | 104 | 61 | 7 | 129 | 258 | 55 | 27 | 75 | 72 |
aHR | 1 | 1.15 | 1.59 | 0.92 | 1 | 1.15 | 0.63 | 0.62 | 1 |
95% CI | Reference | 0.84–1.59 | 0.73–3.46 | 0.74–1.14 | Reference | 0.85–1.55 | 0.40–0.99 | 0.45–0.87 | Reference |
Chronic IHD (I25) | |||||||||
Number of cases (n) | 37 | 26 | 1 | 41 | 97 | 17 | 9 | 28 | 23 |
aHR | 1 | 1.41 | 0.66 | 0.79 | 1 | 0.96 | 0.61 | 0.73 | 1 |
95% CI | Reference | 0.85–2.35 | 0.09–4.85 | 0.54–1.14 | Reference | 0.57–1.63 | 0.28–1.35 | 0.42–1.28 | Reference |
Myocardial infarction (I21–I24) | |||||||||
Number of cases (n) | 25 | 26 | 2 | 30 | 90 | 16 | 7 | 24 | 18 |
aHR | 1 | 2.24 | 2.72 | 0.63 | 1 | 1.07 | 0.57 | 0.78 | 1 |
95% CI | Reference | 1.28–3.91 | 0.62–11.99 | 0.41–0.95 | Reference | 0.62–1.84 | 0.23–1.41 | 0.41–1.47 | Reference |
Stroke subtypes | |||||||||
Ischemic stroke (I63) | |||||||||
Number of cases (n) | 109 | 74 | 8 | 96 | 265 | 51 | 23 | 70 | 69 |
aHR | 1 | 1.38 | 2.35 | 0.72 | 1 | 1.05 | 0.62 | 0.60 | 1 |
95% CI | Reference | 1.03–1.87 | 1.12–4.89 | 0.57–0.91 | Reference | 0.77–1.42 | 0.38–1.01 | 0.42–0.84 | Reference |
Other stroke (I67–I69) | |||||||||
Number of cases (n) | 27 | 27 | 3 | 42 | 69 | 17 | 11 | 28 | 20 |
aHR | 1 | 1.93 | 3.06 | 1.18 | 1 | 1.40 | 1.00 | 0.89 | 1 |
95% CI | Reference | 1.12–3.32 | 0.89–10.50 | 0.80–1.74 | Reference | 0.81–2.40 | 0.46–2.15 | 0.49–1.59 | Reference |
Cerebral infarction without ischemic stroke (I65–I66) | |||||||||
Number of cases (n) | 18 | 10 | 2 | 23 | 62 | 13 | 9 | 18 | 13 |
aHR | 1 | 0.98 | 3.09 | 0.69 | 1 | 1.13 | 1.47 | 0.84 | 1 |
95% CI | Reference | 0.45–2.14 | 0.68–13.95 | 0.42–1.11 | Reference | 0.62–2.08 | 0.60–3.56 | 0.40–1.74 | Reference |
Hemorrhagic stroke (I60–I62) | |||||||||
Number of cases (n) | 25 | 15 | 1 | 23 | 52 | 5 | 3 | 14 | 8 |
aHR | 1 | 1.16 | 1.14 | 0.87 | 1 | 0.51 | 0.71 | 1.03 | 1 |
95% CI | Reference | 0.61–2.21 | 0.15–8.59 | 0.53–1.43 | Reference | 0.20–1.29 | 0.18–2.80 | 0.42–2.51 | Reference |
