Figure 1

Evolutionary dynamics of NFATs across vertebrates. (A) A phylogenetic tree representing the evolutionary relationship among NFATs across vertebrate and invertebrate taxa. (B) NFAT5 phylogenetic tree is expanded to illustrate its detailed evolutionary divergence across vertebrates and invertebrates. (C) A phylogenetic tree representing the basal region of NFAT5, including two clades of Nephrozoa (Deuterostomia and Protostomia). Black dots on the major nodes represent maximum likelihood bootstrap (> 97) and Bayesian posterior probability (> 0.98) support values. Representative species in major vertebrate branches are illustrated as black silhouette images (http://phylopic.org/). Red, blue, light green, dark green, purple, orange, and pink branches correspond to mammal, bird, reptile, amphibian, fish, Deuterostomia, and Protostomia, respectively.