Figure 7

\(\overline{\textit{AUROC}}\) curves for the clinical case at three different orientations of the NOVCoDA with respect to direction of the incident proton beam. The figure summarizes the calculated \(\overline{AUROC}\) values using only FN and only PG distributions reconstructed using the LM-MLEM algorithm as well as for the combination of FN and PG distributions for an orientation of \(\theta = 0 ^{\circ }\) (a), \(\theta = 45 ^{\circ }\) (b) and \(\theta = 90 ^{\circ }\) (c), as well as the \(\theta = 90 ^{\circ }\) case with the estimated effects of time, energy, and position resolutions (and segmentation of a realistic detector) included in (d). Statistical uncertainties in terms of one standard deviation of the \(\overline{AUROC}\) are also shown explicitly as a narrow band around each curve.