Figure 1
Transcriptomic analysis reveals increased immune response and oligodendrocyte development in somatosensory cortex. (A) Workflow of current study summarizing the genotypes, stages, cell types, and molecular techniques used. (B) Number of protein coding genes that were differentially expressed (false discovery rate < 0.05) in the somatosensory cortex of male (M) and female (F) Pten+/− mice at P30 ( male: n=3 for wild-type, and n=2 for Pten+/−; female: n=3 for wild-type and Pten+/−) and P42 (n = 3 for each group). Differentially expressed genes (DEGs) are stratified by their percentage fold change (Pten+/− vs. wild-type). Age and sex-independent analysis after pooling P30M, P30F, P42M and P42F groups; M (P30 + P42), male-specific analysis after pooling P30M and P42M groups; F (P30 + P42), female-specific analysis; P30 (F + M), P30-specific analysis after pooling P30F and P30M groups; P42 (F + M), P42-specific analysis after pooling P42F and P42M groups. (C) Top five upregulated Gene Ontology (GO) terms in each group. (D) Top five downregulated GO terms in each group.
