Figure 3
Transcriptomic analysis of Pten+/− primary neural cells reveals major perturbation of immediate early genes in neurons. (A) The differentially expressed DEGs) are stratified by the percentage fold-change in primary cultures of neural progenitor cells (NPCs), astrocytes (ASTs) and primary cortical neurons (PCNs) from Pten+/− (n = 3) and wild-type littermate control (WT) (n = 3) mice. (B) The five most significantly upregulated Gene Ontology (GO) terms (false discovery rate [FDR] < 0.05) enriched in Pten+/− primary neural cells. (C) Downregulated GO terms (FDR < 0.05) enriched in Pten+/− primary neural cells. No enriched GO terms in NPC and AST. (D) The 10 most significantly upregulated canonical pathways (FDR < 0.05) enriched in Pten+/− primary neural cells. (E) Downregulated canonical pathways (FDR < 0.05) enriched in Pten+/− primary neural cells.
