Figure 6
Linking Pten haploinsufficiency to intelligence, cognitive function and schizophrenia. Gene expression fold-change dimensionality comparison of common differentially expressed genes (DEGs) between Pten+/− and Nes-KO (A) primary cultures of neurons and (B) astrocytes (ASTs). R: Spearman’s correlation coefficient. Overlapping (C) upregulated and (D) downregulated differentially expressed proteins (DEPs) in the somatosensory cortex of Pten+/− mice with DEGs from Pten+/− (HET) and Nes-KO (KO) neural cells. Statistical analysis of enrichment was performed using SuperExactTest. (E) Enrichment of DEPs and DEGs in the somatosensory cortex of Pten+/− mice and translated DEGs in neural cells converging with DEPs and all translated DEGs (adding up translated DEGs from all neural cells) within genes identified in GWAS of neurological diseases and traits. Dots enclosed by a black circle represent enrichment with FDR < 0.05. Dots enclosed by a red circle represent enrichment with FDR < 0.1. Statistically significant enrichment was calculated using an FDR-corrected cumulative hypergeometric test.
