Figure 3
Characteristics of m6A methylation modification patterns. (A) Consensus clustering analysis of m6A regulators. Consensus clustering matrix for k = 2. Cluster A, 1; Cluster B, 2. (B) PCA analysis of m6A regulators. Samples in cluster A, blue dots; Samples in cluster B, yellow dots. (C) Unsupervised clustering of m6A regulators in OSCC patients from TCGA and GSE41613 cohort. Fustat, gender, age, project and m6Acluster were used as patient annotations. High expression, red; low expression, blue. (D) The heatmap of GSVA showing KEGG pathways in each m6A modification patterns. Red represented activated pathways and blue represented inhibited pathways. KEGG pathways14,15,16 were downloaded from the website (http://www.gsea-msigdb.org/). (E) ssGSEA of immune cells infiltration in individual m6A modification patterns. Cluster A, bule; Cluster B, yellow. Top edge of box: upper quartile; bottom edge of box: lower quartile; Internal horizontal line: median. Dots above and below: outliers. *p < 0.05; **p < 0.01; ***p < 0.001; ns no statistical significance.
