Figure 1 | Scientific Reports

Figure 1

From: Distinct mutational pattern of T-cell large granular lymphocyte leukemia combined with pure red cell aplasia: low mutational burden of STAT3

Figure 1

Oncoplot of targeted gene mutations in pure red cell aplasia (PRCA, n = 3), T-cell large granular lymphocyte leukemia (T-LGL, n = 25) and T-LGL combined with PRCA (T-LGL + PRCA, n = 16). Among 84 genes tested, 28 genes in which one or more potential somatic mutations were detected were shown. The genes that were not detected any mutation were removed and are shown in Supplementary Table 5. In STAT3 mutation, variant allele fraction (VAF) percentage was shown in numbers and arranged in order of VAF (%). In some other mutations, the VAF was shown in numbers. Bottom annotations represent clinical parameters at diagnosis and treatment responses. Lower than 10 g/dL of hemoglobin was marked as “Low” and if it was higher than 10 g/dL, marked as “Normal”. Absolute neutrophil count (ANC) cut-off value was 1.8 × 109/L. Conventional cytogenetic results showed a normal karyotype in 42 patients, except for two patients (Y chromosome loss, 26.1% in patient number 9 and 20.0% in patient number 17). Treatment response definitions are described in the “Methods” section.

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