Table 1 Characteristics of the study population.

	PRCA (n = 3)	T-LGL (n = 25)	T-LGL + PRCA (n = 16)	P-value^↑
Age (years)	53 (50.5–64.5)	55 (45–70)	71 (56–77)	0.048
Male/Female (number)	1/2	11/14	6/10	0.680
Autoimmune diseases* (number)	0	2 (8.0%)	1 (6.3%)	1.000
Hemoglobin (g/dL)	7.2 (6.2–7.4)	12.8 (9.2–14.0)	6.7 (5.7–7.6)	< 0.001
Absolute reticulocyte count (× 10⁹/L)	7.2	51.1 (42.9–71.6)	16.9 (5.8–23.5)	< 0.001
Absolute lymphocyte count (× 10⁹/L)	0.8 (0.7–1.3)	3.9 (2.3–6.2)	1.0 (0.7–2.1)	< 0.001
Absolute neutrophil count (× 10⁹/L)	4.2 (3.5–5.2)	1.1 (0.5–1.3)	1.3 (1.0–2.0)	0.040
Platelet count (× 10⁹/L)	203 (192–252)	213 (149–272)	217 (170–360)	0.521
RBC transfusion dependency (number)	3 (100%)	2 (8.0%)	9 (56.3%)	0.012
Infection history (number)	1 (33.3%)	10 (40.0%)	3 (18.8%)	0.187
Treatment received (number)	2 (66.6%)	18 (72.0%)	13 (81.3%)	0.713
Bone marrow cellularity (%)	25.0 (25.0–35.0)	45.0 (31.3–65.0)	40.0 (25.0–55.0)	0.405
STAT3 mutation (number)	0	9 (36.0%)	8 (50.0%)	0.280
STAT3 VAF (%)	–	24.8 (22.1–29.4)	4.5 (3.5–6.6)	< 0.001

The values are presented as the median value or number and interquartile range or percentage in parentheses.
*Comorbid autoimmune diseases included Behcet’s disease and systemic lupus erythematosus in T-LGL and rheumatic arthritis in T-LGL + PRCA.
^↑P-values compare T-LGL with T-LGL + PRCA.
PRCA, pure red cell aplasia; T-LGL, T-cell large granular leukemia; T-LGL + PRCA, T-LGL combined with PRCA; STAT3, signal transducer and activator of transcription 3; VAF, variant allele frequency.

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