Table 3 Associations of single htSNP in IL1B with lung cancer risk.

From: Common variants of pro-inflammatory gene IL1B and interactions with PPP1R13L and POLR1G in relation to lung cancer among Northeast Chinese

Type/modela/rs

Genotype

Controls 633

n (%)

Cases 627

n (%)

OR (95 CI)b,c

P valuec

AICd

Whole group: lung cancer

 rs1143633 (A>G)

  Co-dominant

A/A

169 (28.2%)

224 (36.4%)

1.00

  

G/A

311 (51.9%)

289 (47%)

0.68 (0.53–0.89)

0.0044

1651.4

G/G

119 (19.9%)

102 (16.6%)

0.62 (0.44–0.87)

  

  Dominant

A/A

169 (28.2%)

224 (36.4%)

1.00

  

G/A-G/G

430 (71.8%)

391 (63.6%)

0.67 (0.52–0.85)

0.0012

1649.7

  Recessive

A/A-G/A

480 (80.1%)

513 (83.4%)

1.00

  

G/G

119 (19.9%)

102 (16.6%)

0.78 (0.58–1.05)

0.1

1657.6

  Over-dominant

A/A-G/G

288 (48.1%)

326 (53%)

1.00

  

G/A

311 (51.9%)

289 (47%)

0.81 (0.65–1.02)

0.077

1657.1

  Log-additive

–

–

–

0.77 (0.65–0.91)

0.0021

1650.8

 rs3136558 (T>C)

  Co-dominant

T/T

223 (37.2%)

214 (34.8%)

1.00

  

C/T

296 (49.4%)

293 (47.6%)

1.02 (0.79–1.31)

0.079

1657.2

C/C

80 (13.4%)

108 (17.6%)

1.46 (1.03–2.06)

  

  Dominant

T/T

223 (37.2%)

214 (34.8%)

1.00

  

C/T-C/C

376 (62.8%)

401 (65.2%)

1.11 (0.88–1.41)

0.38

1659.5

  Recessive

T/T-C/T

519 (86.6%)

507 (82.4%)

1.00

  

C/C

80 (13.4%)

108 (17.6%)

1.44 (1.05–1.98)

0.025

1655.2

  Over-dominant

T/T-C/C

303 (50.6%)

322 (52.4%)

1.00

  

C/T

296 (49.4%)

293 (47.6%)

0.91 (0.73–1.15)

0.44

1659.6

  Log-additive

–

–

–

1.16 (0.99–1.37)

0.073

1657

 rs1143630 (C>A)

  Co-dominant

C/C

422 (70%)

407 (66.9%)

1.00

  

A/C

164 (27.2%)

190 (31.2%)

1.19 (0.92–1.53)

0.21

1655.7

A/A

17 (2.8%)

11 (1.8%)

0.67 (0.31–1.46)

  

  Dominant

C/C

422 (70%)

407 (66.9%)

1.00

  

A/C-A/A

181 (30%)

201 (33.1%)

1.14 (0.89–1.46)

0.29

1655.7

  Recessive

C/C-A/C

586 (97.2%)

597 (98.2%)

1.00

  

A/A

17 (2.8%)

11 (1.8%)

0.64 (0.29–1.38)

0.25

1655.5

  Over-dominant

C/C-A/A

439 (72.8%)

418 (68.8%)

1.00

  

A/C

164 (27.2%)

190 (31.2%)

1.21 (0.94–1.55)

0.15

1654.7

  Log-additive

–

–

–

1.07 (0.86–1.33)

0.54

1656.5

Histopahtology subgroup: lung squamous cell carcinomae

 rs1143633 (A>G)

  Log-additive

–

–

–

0.59 (0.47–0.75)

< 0.0001

980.8

rs3136558 (T>C)

  Log-additive

–

–

–

1.35 (1.08–1.69)

0.0086

994.5

  1. aDominant model: AB (Heterozygote) + BB (Homozygous variant-type) versus AA (Homozygous wild-type), Recessive model: BB versus AA + AB, Co-dominant model: AB versus AA and BB versus AA, Over-dominant model: AB versus AA + BB, Log-additive model: Analysis of trend where AA is ‘0’, AB is ‘1’ and BB is ‘2’.
  2. bOR (odd ratio), 95% CI (95% confidence interval), adjusted for smoking duration.
  3. cBoldface indicates statistical significance.
  4. dAkaike’s Information Criterion.
  5. eOnly list the best significant models.
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