Figure 1 | Scientific Reports

Figure 1

From: Glucagon-like peptide-1 facilitates cerebellar parallel fiber glutamate release through PKA signaling in mice in vitro

Figure 1

GLP-1 enhanced the PF stimulation-evoked EPSCs in mouse cerebellar slices. (A) A diagram showing the parallel fiber (PF) stimulation evoked EPSCs in a cerebellar PC. R, recording electrode; S, stimulation electrode; GC, granule cell. (B) Under voltage-clamp recording mode (Vh = -70 mV), the representative traces showing EPSCs (N1 and N2) evoked by a paired-pulse stimulation (0.2 ms, 10–100 µA; interval: 50 ms) during treatments of ACSF, GLP-1 (100 nM) and washout. (C) The mean (± S.E.M) value showing the time course of N1 during treatments of ACSF, GLP-1 (100 nM) and washout. (D) The mean (± S.E.M) and individual data showing the normalized amplitude of N1 during treatments with ACSF, GLP-1 and washout. (E) The mean (± S.E.M) and individual data showing the N2/N1 ratio during each treatment. *, P < 0.05 versus ACSF, n = 7 cells in each group.

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