Figure 3 | Scientific Reports

Figure 3

From: Glucagon-like peptide-1 facilitates cerebellar parallel fiber glutamate release through PKA signaling in mice in vitro

Figure 3

Inhibition of PKA abolished the GLP-1-induced enhancement of the eEPSCs. (A) The representative traces showing the EPSCs evoked by a paired-pulse stimulation (0.2 ms, 10–100 µA; interval: 50 ms) during treatments of KT5720 (500 nM), KT5720 + GLP-1 (100 nM), and washout of GLP-1. (B) In the presence of KT5720, the mean (± S.E.M) value showing the time course of N1 under control, GLP-1 (100 nM) and washout. (C, D) The mean (± S.E.M) and individual data show the normalized amplitude of N1 (C) and N2/N1 ratio (D) during treatments with KT5720, KT5720 + GLP-1, and washout of GLP-1. *, P < 0.05 versus control (KT5720), n = 7 cells in each group.

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