Figure 4 | Scientific Reports

Figure 4

From: Glucagon-like peptide-1 facilitates cerebellar parallel fiber glutamate release through PKA signaling in mice in vitro

Figure 4

Blockade postsynaptic PKA, failed to prevent the GLP-1-induced enhancement of the PF-PC eEPSCs. (A) Using PKI containing pipette solution, the representative traces showing EPSCs (N1 and N2) evoked by a paired-pulse stimulation (0.2 ms, 10–100 µA; interval: 50 ms) during treatments of ACSF, GLP-1 (100 nM) and washout. (B) The mean (± S.E.M) value showing the time course of N1 during treatments of ACSF, GLP-1 (100 nM) and washout. (C) The mean (± S.E.M) and individual data showing the normalized amplitude of N1 during treatments with ACSF, GLP-1 and washout. (D) The mean (± S.E.M) and individual data showing the N2/N1 ratio during each treatment. *, P < 0.05 versus ACSF, n = 7 cells in each group.

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