Table 1 Maternal and infant characteristics among 4,409,716 Births in Canada, 2004–2020 in Canada, by conception season as specified.

From: Association of maternal depression and hypothyroidism with infant gastroschisis: a population-based cohort study in Canada

Characteristic

Conception in Winter (Exposed) (n = 3689 855, 83.7%)

Conception in Summer (Un-exposed) (n = 719 861, 16.3%)

p value for difference b

Period of birth

  

 < 0.001

 2004–2007

866,540 (23.5)

170,620 (23.7)

 

 2008–2011

941,343 (25.5)

184,735 (25.6)

 

 2012–2015

946,557 (25.7)

183,288 (25.5)

 

 2016–2019

935,415 (25.3)

181,218 (25.2)

 

Geographic region

  

 < 0.001

 Far North

43,630 (1.2)

8537 (1.2)

 

 North

209,264 (5.7)

41,134 (5.7)

 

 North-to-South

1,503,553 (40.7)

296,323 (41.2)

 

 South

1,933,408 (52.4)

373,867 (51.9)

 

Maternal age at conception (year)

  

 < 0.01

 13–18

134,246 (3.6)

26,690 (3.7)

 

 19–23

5,16,704 (14.0)

100,343 (13.9)

 

 24–28

1,056,251 (28.6)

207,029 (28.8)

 

 29–33

1,235,325 (33.5)

240,633 (33.4)

 

 34–44

747,329 (20.3)

145,166 (20.2)

 

Residence

 Rural

619,244 (16.8)

122,112 (17.0)

 < 0.001

 Urban

3,070,611 (83.2)

597,749 (81.7)

 

 Parity

  

 < 0.0001

 1st child

1,280,636 (34.7)

248,368 (34.5)

 

 2nd child

1,008,019 (27.3)

198,754 (27.6)

 

  ≥ 3rd child

638 675 (17.3)

123,629 (17.2)

 

 Missing

762,525 (20.7)

149,110 (20.7)

 

Multifetal pregnancy

 Yes

52,985 (1.4)

9908 (1.4)

 < 0.001

 No

3,636,870 (98.6)

709, 953 (98.6)

 

Substance use

 Yes

37,669 (1.0)

6758 (0.9)

 < 0.001

 No

365,186 (99.0)

713,103 (99.1)

 

Depressive disorder

 Yes

11,833 (0.3)

2402 (0.3)

0.08

 No

3,678,022 (99.7)

717,459 (99.7)

 

Hypothyroidism

 Yes

26,719 (0.7)

5188 (0.7)

0.75

 No

3,663,136 (99.3)

566,953 (99.4)

 

Gestational diabetes

 Yes

240,089 (6.5)

45,886 (6.4)

 < 0.001

 No

3,449,766 (93.5)

6,73,975 (93.6)

 

Tobacco smoking

 Yes

19,092 (0.5)

3742 (0.5)

0.80

 No

3,170,763 (99.5)

716,119 (99.5)

 

Obesity

 Yes

59,552 (1.6)

11,790 (1.6)

0.14

 No

3,630,303 (98.4)

70,807 (98.4)

 

Chronic illnessa

 Yes

10,750 (1.5)

55,637 (1.5)

0.36

 No

3,634,211 (98.5)

368,868 (98.5)

 

Infant sex

 Male

1,892,351 (51.3)

368,869 (51.2)

0.50

 Female

1,797,504 (48.7)

350,993 (48.8)

 
  1. aIncluding pre-gestational type 1 or type 2 diabetes, specified mental disorders, migraine, lupus, epilepsy, hyperthyroidism or thyroiditis among mothers.
  2. bP values for difference between exposed and un-exposed groups were calculated using χ2 test.