Table 1 Univariate analysis and multivariate analysis of patients’ characters in DILI and control groups.
From: Increased TG to HDL-C ratio is associated with severity of drug-induced liver injury
Variable | DILI | Control | HBV | ||||||
|---|---|---|---|---|---|---|---|---|---|
p1 | AOR (95%CI) * | p2 | p1 | AOR (95%CI) ** | p2 | ||||
Sex | < 0.01 | 0.55 (0.34–0.9) | 0.02 | < 0.01 | 0.21 (0.12–0.35) | < 0.01 | |||
Female (N%) | 57.92 | 44.31 | 21.84 | ||||||
Male (N%) | 42.08 | 55.69 | 78.16 | ||||||
Age (mean ± SD) | 50.97 ± 13.34 | 55.15 ± 14.92 | < 0.01 | 0.67 (0.39–1.12) | 0.13 | 43.17 ± 12.06 | < 0.01 | 2.96 (1.69–5.18) | < 0.01 |
< 60 | 71.49 | 58.54 | 90.04 | ||||||
≥ 60 | 28.51 | 41.46 | 9.96 | ||||||
Smoking | 0.55 | – | – | < 0.01 | 0.89 (0.48–1.64) | 0.70 | |||
No (N%) | 75.57 | 73.17 | 59.39 | ||||||
Yes (N%) | 24.43 | 26.83 | 40.61 | ||||||
Alcoholic abuse | 0.97 | – | – | < 0.01 | 0.97 (0.52–1.8) | 0.92 | |||
No (N%) | 74.66 | 74.80 | 56.32 | ||||||
Yes (N%) | 25.34 | 25.20 | 43.68 | ||||||
Hypertension | < 0.01 | 0.49 (0.27–0.88) | 0.02 | < 0.01 | 2.48 (1.34–4.61) | < 0.01 | |||
No (N%) | 80.09 | 60.16 | 90.42 | ||||||
Yes (N%) | 19.91 | 39.84 | 9.58 | ||||||
Heart disease | 0.05 | 0.63 (0.22–1.82) | 0.40 | 0.06 | 1.1 (0.27–4.49) | 0.89 | |||
No (N%) | 95.48 | 90.65 | 98.47 | ||||||
Yes (N%) | 4.52 | 9.35 | 1.53 | ||||||
Diabetes | < 0.01 | 0.41 (0.17–1.01) | 0.05 | 0.16 | – | – | |||
No (N%) | 94.57 | 84.55 | 91.19 | ||||||
Yes (N%) | 5.43 | 15.45 | 8.81 | ||||||
Malignant disease | 0.02 | 11.39 (4.96–26.15) | < 0.01 | 1.00 | – | – | |||
No (N%) | 84.16 | 95.12 | 100.00 | ||||||
Yes (N%) | 15.84 | 4.88 | 0.00 | ||||||
Allergic history | < 0.01 | 1.92 (1.01–3.65) | 0.05 | < 0.01 | 3.84 (1.98–7.43) | < 0.01 | |||
No (N%) | 79.64 | 87.40 | 93.10 | ||||||
Yes (N%) | 20.36 | 12.60 | 6.90 | ||||||
Family chronic disease | 0.04 | 3.33 (1.23–9.04) | 0.02 | < 0.01 | 0.44 (0.23–0.84) | 0.01 | |||
No (N%) | 90.50 | 95.53 | 80.08 | ||||||
Yes (N%) | 9.50 | 4.47 | 19.92 | ||||||
Dyslipidemia | < 0.01 | 4.6 (2.81–7.54) | < 0.01 | 0.01 | 2.12 (1.37–3.29) | < 0.01 | |||
No (N%) | 36.20 | 67.48 | 48.66 | ||||||
Yes (N%) | 63.80 | 32.52 | 51.34 | ||||||
Medication type | < 0.01 | 0.24 (0.18–0.33) | < 0.01 | ||||||
Chinese herbal medicines | 50.68 | 5.69 | |||||||
Both | 15.38 | 22.76 | |||||||
Western medicines | 33.94 | 71.54 | |||||||
