Table 4 Dyslipidemia and TG/HDL-C ratio in classes of DILI and control group.
From: Increased TG to HDL-C ratio is associated with severity of drug-induced liver injury
Variable | Cho (mmol/L) | TG (mmol/L) | HDL-C (mmol/L) | LDL-C (mmol/L) | FFA (µmol/dL) | TG/HDL-C | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
(Mean ± SD) | P | (Mean ± SD) | P | (Mean ± SD) | P | (Mean ± SD) | P | (Mean ± SD) | P | (Mean ± SD) | P | |
DILI | 5.07 ± 2.93 | 1.99 ± 1.26 | 1.03 ± 0.53 | 2.79 ± 2.37 | 68.98 ± 32.48 | 3.26 ± 4.17 | ||||||
Control | 4.28 ± 0.99 | < 0.01 | 1.29 ± 0.85 | < 0.01 | 1.15 ± 0.33 | < 0.01 | 2.54 ± 0.75 | 0.14 | 45.64 ± 26.52 | < 0.01 | 1.8 ± 8.51 | 0.02 |
HBV | 4.04 ± 1.27 | < 0.01 | 1.47 ± 0.82 | < 0.01 | 0.99 ± 0.48 | 0.34 | 2.08 ± 0.76 | < 0.01 | 68.08 ± 33 | 0.76 | 2.73 ± 5.05 | 0.22 |
Classes of drugs | ||||||||||||
Chinese herbal medicines | 4.83 ± 3.3 | > 0.05 | 2.01 ± 1.11 | > 0.05 | 0.94 ± 0.52b | 2.57 ± 2.67 | > 0.05 | 72.29 ± 32.69 | > 0.05 | 3.75 ± 4.42a | ||
Western medicines | 5.49 ± 2.55 | 1.79 ± 1.42 | 1.19 ± 0.5a | 3.1 ± 1.96 | 63.81 ± 32.16 | 2.38 ± 3.85b | ||||||
Both | 4.94 ± 2.26 | 2.35 ± 1.32 | 1 ± 0.58ab | 2.83 ± 2.06 | 69.06 ± 31.9 | 3.53 ± 3.72ab | ||||||
Patterns of liver injury | ||||||||||||
Hepatocellular | 4.31 ± 1.6bc | 1.81 ± 1.09 | > 0.05 | 0.98 ± 0.44 | > 0.05 | 2.3 ± 1.44b | 73.76 ± 34.43 | > 0.05 | 2.96 ± 3.78 | > 0.05 | ||
Cholestatic | 5.9 ± 3.76a | 2.16 ± 1.46 | 1.11 ± 0.62 | 3.36 ± 3.02a | 65.75 ± 31.52 | 3.48 ± 4.63 | ||||||
Mix | 4.38 ± 1.68b | 1.88 ± 0.87 | 0.92 ± 0.46 | 2.21 ± 1.37bc | 66.58 ± 29.32 | 3.35 ± 3.59 | ||||||
Severity of DILI | ||||||||||||
Level 0–2 | 4.79 ± 1.69 | 0.12 | 1.62 ± 0.7 | < 0.01 | 1.22 ± 0.5 | < 0.01 | 2.54 ± 1.02 | 0.11 | 62.34 ± 31.89 | < 0.01 | 1.64 ± 1.03 | < 0.01 |
Level ≥ 3 | 5.63 ± 4.92 | 2.72 ± 1.2 | 0.65 ± 0.42 | 3.28 ± 4.18 | 82.45 ± 33.29 | 6.55 ± 5.43 | ||||||