Figure 7
From: Structural and functional analysis of the newt lymphatic system
Lymphatic endothelial cell marker expression in newly regenerated lymphatics. Histological sections showing the regenerated lymphatic heart (LH) (yellow arrowhead) and the adjacent rib bone (blue arrowhead) in the abdominal region 120 days post complete microsurgical excision. The newly regenerated LHs had identical shape, size, structure, position, and function as the original LH. In addition, the newly regenerated LH demonstrated strong expression of lymphatic endothelial cell markers VEGFR-3 and LYVE-1 and pan-endothelial marker CD-31. The uptake of rhodamine-dextran dye confirmed the lymphatics were fully functional (Scale bars = 200 μm).
