Table 2 List of DEGs analyzed in RT-qPCR and their reported changes in association with AD.

From: Transcriptomic analysis of glutamate-induced HT22 neurotoxicity as a model for screening anti-Alzheimer’s drugs

Gene

Changes observed in AD patients

Apoe

Apolipoprotein E

Upregulation in AD brain16

Ptgs2

Prostaglandin-endoperoxide synthase 2 (cyclooxygenase 2)

Upregulation in AD brain17

Rest

Repressor element 1 silencing transcription factor (neuron-restrictive silencer factor)

Downregulation in AD brain18,19

Zbed6

Zinc finger BED domain-containing protein 6

Upregulation in blood sample20

Loxl2

Lysyl oxidase-like 2

Upregulation in AD brain21

Ccl2

Chemokine C–C motif ligand-2 (monocyte chemotactic protein-1)

Upregulation in AD brain and CSF of AD patients22,23

Synpo

Synaptopodin

Downregulation in AD brain24

Ablim1

Actin-binding LIM protein 1

AD-risk associated SNPs (rs6646, rs727532) in AD brain25

Glis3

GLIS Family Zinc Finger 3

AD-risk associated SNPs (rs514716) in CSF of AD patients26

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