Figure 3
From: An injectable copolymer of fatty acids (ARA 3000 BETA) as a promising treatment for osteoarthritis
ARA 3000 BETA protected bone from OA-associated alterations. (A) Representative images of knee joint bone tissues in healthy (H) mice and CIOA mice not treated (OA) or treated with four intra-muscular (IM) injections or one (IA1) or two intra-articular (IA2) injections of ARA 3000 BETA (Ara) after micro-CT analysis. (B) Histomorphometric analysis of epiphysis bone volume (BV) indicative of sclerosis, sub-chondral bone volume (BV), thickness and bone surface/bone volume (BS/BV) parameters, indicative of bone surface alteration at the interface with cartilage. (C) Histomorphometric analysis of osteophyte bone volume (BV) and surface (BS) at the edges of cartilage in knee joints. Results are expressed as the mean ± SEM; *p < 0.05; **p < 0.01 (ANOVA test with Dunn’s post-test as compared to OA control; n = 15 mice).
