Figure 1 | Scientific Reports

Figure 1

From: Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5′-termini of RNA and polymerase function

Figure 1

Summary of IAV phosphorylation sites in the polymerase subunits. (A) Phosphorylation sites of polymerase subunits occurring in vivo are listed, whereas phosphorylations detected only by in vitro experiments were not included. The virus strains in which the modifications were detected are indicated (WSN: A/WSN/1933 (H1N1); Vic: A/Victoria/3/75 (H3N2); SC35: A/Seal/Massachusetts/1/80 (H7N7); SC35M: A/Seal/Massachusetts/1/80 (H7N7) mouse-adapted). (B) The position of PB2 T471 and PA Y393, S395 phosphorylation sites within the polymerase complex are shown in red, the PB2, PB1, and PA subunits and the 5′ vRNA and 3′ vRNA promoters are displayed. The structure is shown in two different degrees of inclination to allow optimal visibility of the phosphorylation sites, boxed areas are enlarged. The structures (PDB: 4WSB) were displayed using Pymol.

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