Table 3 Effect of rs1059491 genotype on cardiometabolic abnormalities under dominant model (GT + GG versus TT).

From: Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults

Cardiometabolic abnormality

Model 1

Model 2

Model 3

OR

95%CI

P

OR

95%CI

P

OR

95%CI

P

Overweight combined obesity

(BMI ≥ 25 kg/m2)

0.42

0.22‒0.82

0.011

0.46

0.22‒0.96

0.037

–

–

–

Elevated blood pressure

(SBP/DBP ≥ 130/85 mmHg)

1.19

0.63‒2.27

0.591

1.67

0.83‒3.36

0.149

2.13

1.01‒4.48

0.046

Impaired fasting glucose

(FPG ≥ 5.60 mmol/L (100 mg/dL))

0.29

0.09‒0.98

0.047

0.33

0.09‒1.14

0.080

0.34

0.10‒1.21

0.097

Elevated triglycerides

(fasting triglycerides ≥ 1.7 mmol/L (150 mg/dL))

0.24

0.08‒0.69

0.008

0.25

0.08‒0.74

0.013

0.28

0.09‒0.88

0.030

Elevated TC

(fasting TC ≥ 5.2 mmol/L (200 mg/dL))

0.71

0.33‒1.52

0.379

0.79

0.36‒1.72

0.552

0.83

0.38 ‒ 1.82

0.635

Decreased HDL-C

(HDL-C < 1.0 mmol/L (40 mg/dL))

0.64

0.15‒2.79

0.552

0.78

0.17‒3.54

0.742

0.96

0.20‒4.69

0.959

Elevated LDL-C

(fasting LDL-C ≥ 3.40 mmol/L (130 mg/dL))

0.96

0.32‒2.85

0.942

1.04

0.35‒3.13

0.940

1.15

0.38‒3.49

0.809

Dyslipidaemia

0.35

0.17‒0.75

0.007

0.37

0.17‒0.83

0.015

0.41

0.18‒0.93

0.032

  1. Model 1: Unadjusted.
  2. Model 2: Adjusted for sex and age.
  3. Significant are in value [bold].
  4. Model 3: Adjusted for sex, age and weight status (normal weight, overweight or obese).
  5. BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.
  6. Dyslipidaemia was defined by the presence of one or more of the followingcomponents conditions: TC ≥ 5.20 mmol/L (200 mg/dL), LDL-C ≥ 3.40 mmol/L (130 mg/dL), HDL-C < 1.00 mmol/L (40 mg/dL), TG ≥ 1.70 mmol/L (150 mg/dL), or if they were taking anti-dyslipidaemia medication.
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