Table 1 Demographic and clinical characteristics of patients stratified by SUA.

From: The association between serum uric acid and cognitive performance in patients with ischemic stroke is modified by estimated glomerular filtration rate

 

Overall

Uric acid (µmol/L)

P value

Q1(58.0–246.0)

Q2(247.0–287.0)

Q3(288.0–339.0)

Q4(340.0–611.0)

n = 608

n = 151

n = 150

n = 155

n = 152

Age, y

66.6 ± 4.1

66.4 ± 4.1

66.8 ± 4.3

66.9 ± 4.0

66.2 ± 4.2

0.463

Male, n (%)

316 (52.0)

46 (30.5)

67 (44.7)

87 (56.1)

116 (76.3)

 < 0.001

BMI,a kg/m2

25.0 ± 3.6

24.6 ± 3.3

24.9 ± 3.6

24.7 ± 3.6

25.6 ± 3.7

0.054

Education (> 6 years), n (%)

200 (32.9)

28 (18.5)

36 (24.0)

59 (38.1)

77 (50.7)

 < 0.001

Systolic blood pressure on admission, mmHg

171.9 ± 20.2

172.4 ± 19.4

171.4 ± 18.5

172.9 ± 21.9

170.8 ± 21.1

0.795

Diastolic blood pressure on admission, mmHg

92.9 ± 12.2

90.2 ± 12.1

93.0 ± 12.4

93.8 ± 12.7

94.6 ± 11.5

0.011

Smoking, n (%)

 Never

355 (58.5)

118 (78.1)

98 (65.8)

80 (51.6)

59 (38.8)

 < 0.001

 Former

64 (10.5)

9 (6.0)

12 (8.1)

19 (12.3)

24 (15.8)

 

 Current

188 (31.0)

24 (15.9)

39 (26.2)

56 (36.1)

69 (45.4)

 

Alcohol drinking, n (%)

 Never

389 (64.0)

119 (78.8)

105 (70.0)

96 (61.9)

69 (45.4)

 < 0.001

 Former

52 (8.6)

11 (7.3)

11 (7.3)

13 (8.4)

17 (11.2)

 

 Current

167 (27.5)

21 (13.9)

34 (22.7)

46 (29.7)

66 (43.4)

 

Stroke subtypes

0.728

 Large artery

281 (46.2)

71 (47.0)

72 (48.0)

66 (42.6)

72 (47.4)

 

 Small vessel occlusion

309 (50.8)

72 (47.7%)

75 (50.0%)

83 (53.5%)

79 (52.0%)

 

 Cardioembolism

13 (2.1)

6 (4.0%)

2 (1.3%)

4 (2.6%)

1 (0.7%)

 

 Other determined etiology

3 (0.5)

1 (0.7%)

1 (0.7%)

1 (0.6%)

0 (0.0%)

 

 Undetermined etiology

2 (0.3)

1 (0.7%)

0 (0.0%)

1 (0.6%)

0 (0.0%)

 

Diabetes mellitus,b n (%)

50 (8.2)

21 (13.9)

13 (8.7)

10 (6.5)

6 (3.9)

0.013

Hypertension, n (%)

361 (59.4)

89 (58.9)

90 (60.0)

95 (61.3)

87 (57.2)

0.906

Laboratory results

 Total cholesterol, mmol/L

5.7 ± 1.2

5.7 ± 1.1

5.7 ± 1.1

5.6 ± 1.2

5.8 ± 1.2

0.393

 Triglyceride, mmol/L

1.6 ± 0.9

1.5 ± 0.7

1.6 ± 0.8

1.7 ± 1.2

1.7 ± 1.0

0.088

 Folate, ng/mL

7.5 ± 3.3

7.9 ± 3.7

7.6 ± 3.4

7.2 ± 3.1

7.1 ± 3.0

0.138

 Vitamin B12, pmol/L

399.5 ± 165.5

413.3 ± 177.6

376.1 ± 110.0

395.1 ± 176.4

413.7 ± 185.0

0.157

 Uric acid, µmol/L

298.6 ± 75.4

212.4 ± 28.9

267.2 ± 11.8

313.6 ± 14.8

399.8 ± 52.2

 < 0.001

 Fasting glucose, mmol/L

6.1 ± 1.8

6.5 ± 2.4

6.1 ± 1.7

6.0 ± 1.7

5.9 ± 1.2

0.019

 Estimated glomerular filtration rate, ml/min/1.73m2

88.4 ± 12.9

92.5 ± 8.8

90.1 ± 9.9

88.3 ± 12.8

82.7 ± 16.6

 < 0.001

 UACR, mg/g

83.6 ± 314.2

90.7 ± 392.5

71.8 ± 133.0

92.4 ± 443.8

79.4 ± 159.1

0.933

Neural function assessment, mean (SD)

 MMSE score, mean ± SD (range 0–30)

21.4 ± 2.1

21.6 ± 1.8

21.6 ± 1.8

21.5 ± 2.1

21.1 ± 2.6

0.101

 MoCA score, mean ± SD (range 0–30)

17.9 ± 2.3

18.2 ± 2.0

18.0 ± 2.1

18.1 ± 2.4

17.4 ± 2.7

0.017

 NIHSS score, mean ± SD (range 0–42)

5.0 ± 2.2

5.3 ± 2.3

4.9 ± 2.3

4.9 ± 2.2

4.9 ± 2.1

0.393

  1. SUA serum uric acid, BMI body mass index, UACR urine albumin creatinine ratio, MMSE Mini-Mental State Examination, MoCA Montreal Cognitive Assessment, NIHSS National Institutes of Health Stroke Scale.
  2. Values are presented as mean ± SD for continuous variables and n (%) for categorical variables.
  3. aBMI was calculated as weight in kilograms divided by height in meters squared.
  4. bDiabetes mellitus was defined as self-reported physician diagnosed diabetes.
  5. CHypertension was defined as self-reported physician diagnosed hypertension.
  6. Q1: quartile 1 (lowest quartile); Q2: quartile 2; Q3: quartile 3; Q4: quartile 4 (highest quartile).
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