Table 2 Linear regression analysis of the association between SUA levels and cognitive measures.

From: The association between serum uric acid and cognitive performance in patients with ischemic stroke is modified by estimated glomerular filtration rate

SUA level (µmol/L)

No. of patients (%)

Crude

Model 1

Model 2

ß (95%CI)

P

ß (95%CI)

P

ß (95%CI)

P

MMSE

 Q1 (58.0–246.0)

151(24.8)

0

 

0

 

0

 

 Q2 (247.0–287.0)

150(24.7)

0.02 (− 0.45, 0.50)

0.921

0.01 (− 0.46, 0.47)

0.977

0.28 (− 0.13, 0.69)

0.183

 Q3 (288.0–339.0)

155(25.5)

− 0.03 (− 0.50, 0.43)

0.887

− 0.00 (− 0.48, 0.47)

0.984

0.43 (0.01, 0.85)

0.046

 Q4 (340.0–611.0)

152(25.0)

− 0.49 (− 0.96, − 0.02)

0.041

− 0.60 (− 1.11, − 0.10)

0.02

0.45 (− 0.03, 0.92)

0.065

 P for trend

 

− 0.15 (− 0.30, − 0.00)

0.045

− 0.18 (− 0.34, − 0.02)

0.029

0.15 (0.00, 0.30)

0.047

 Q1–Q3 (58.0–339.0)

356(75.0)

0

 

0

 

0

 

 Q4 (340.0–611.0)

152(25.0)

− 0.49 (− 0.87, − 0.10)

0.013

− 0.60 (− 1.00, − 0.21)

0.003

0.15 (− 0.22, 0.52)

0.421

 SUA per 20-unit increase

608(100)

− 0.06 (− 0.11, − 0.02)

0.006

− 0.08 (− 0.13, − 0.04)

 < 0.001

0.02 (− 0.03, 0.06)

0.396

MoCA

 Q1 (58.0–246.0)

151(24.8)

0

 

0

 

0

 

 Q2 (247.0–287.0)

150(24.7)

− 0.17 (− 0.69, 0.35)

0.519

− 0.13 (− 0.65, 0.39)

0.629

0.24 (− 0.19, 0.67)

0.268

 Q3 (288.0–339.0)

155(25.5)

− 0.12 (− 0.64, 0.40)

0.647

− 0.02 (− 0.55, 0.50)

0.926

0.56 (0.12, 1.00)

0.012

 Q4 (340.0–611.0)

152(25.0)

− 0.78 (− 1.30, − 0.26)

0.004

− 0.82 (− 1.38, − 0.26)

0.004

0.60 (0.10, 1.09)

0.018

 P for trend

 

− 0.23 (− 0.39, − 0.06)

0.007

− 0.23 (− 0.41, − 0.05)

0.011

0.22 (0.06, 0.37)

0.007

Q1–Q3 (58.0–339.0)

356(75.0)

0

 

0

 

0

 

 Q4 (340.0–611.0)

152(25.0)

− 0.68 (− 1.10, − 0.26)

0.002

− 0.77 (− 1.21, − 0.32)

 < 0.002

0.25 (− 0.13, 0.64)

0.198

SUA per 20-unit increase

608(100)

− 0.09 (− 0.14, − 0.04)

 < 0.001

− 0.10 (− 0.15, − 0.05)

 < 0.001

0.04 (− 0.01, 0.09)

0.111

  1. Model 1: adjusted for age, gender, BMI, systolic blood pressure, education, diabetes and hypertension history, stroke subtypes, NIHSS scores, smoking and alcohol drinking status, serum total cholesterol, triglyceride, vitamin B12, folate, fasting glucose and UACR.
  2. Model 2: Model 1 + eGFR.
  3. Q1: quartile 1 (lowest quartile); Q2: quartile 2; Q3: quartile 3; Q4: quartile 4 (highest quartile).
  4. ß standardized regression coefficient, CI confidence interval, SUA serum uric acid, eGFR estimated glomerular filtration rate, UACR urine albumin creatinine ratio, NIHSS National Institutes of Health Stroke Scale.
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