Figure 6 | Scientific Reports

Figure 6

From: Revealing the immune cell subtype reconstitution profile in patients from the CLARITY study using deconvolution algorithms after cladribine tablets treatment

Figure 6

Monocyte and macrophage signature score distribution generated by CIBERSORT and xCell between treatment arms in CLARITY. A multivariate linear regression model was built for each cell type to test whether treatment arm is significantly related to the deconvolution score. P-value from F-statistics was used to determine whether the relationship is still significant when model is accounted for patient’s age and gender. Cell types for which either the adjusted p-values for the treatment coefficient or overall F-test adjusted p-value were > 0.1 were considered not significant and marked as ns. Adjusted p-value from F-test (lower row) and adjusted p-value from linear model where only treatment arm was used as a covariate (upper row) are marked as asterisks * < 0.1, ** < 0.01, *** < 0.001.

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