Table 2 Pairwise comparison between flow cytometry data from GSE93777 and corresponding xCell deconvolution cell signatures.

From: Revealing the immune cell subtype reconstitution profile in patients from the CLARITY study using deconvolution algorithms after cladribine tablets treatment

Cell signature

Flow cytometry cell phenotype

Spearman correlation (r)

P-value

FDR

Assessment

xcell.B.cells

B.CELL.rWBC

0.768

< 0.001

0.000

Strong correlation

xcell.Basophils

BASOPHIL.rWBC

0.016

0.802

0.802

No or negative correlation

xcell.CD4.memory.T.cells

MEMORY.CD4.rWBC

0.434

< 0.001

0.000

Moderate correlation

xcell.CD4.naive.T.cells

NAIVE.CD4.rWBC

0.786

< 0.001

0.000

Strong correlation

xcell.CD4.T.cells

CD4.T.rWBC

0.789

< 0.001

0.000

Strong correlation

xcell.CD4.Tcm

MEMORY.CD4.rWBC

0.466

< 0.001

0.000

Moderate correlation

xcell.CD4.Tem

MEMORY.CD4.rWBC

0.523

< 0.001

0.000

Strong correlation

xcell.CD8.naive.T.cells

NAIVE.CD8.rWBC

− 0.141

0.029

0.035

No or negative correlation

xcell.CD8.T.cells

CD8.T.rWBC

0.850

< 0.001

0.000

Strong correlation

xcell.CD8.Tcm

MEMORY.CD8.rWBC

0.488

< 0.001

0.000

Moderate correlation

xcell.CD8.Tem

CD45RA.MEMORY.CD8.rWBC

0.450

< 0.001

0.000

Moderate correlation

xcell.cDC

MDC.rWBC

0.289

< 0.001

0.000

Weak correlation

xcell.Class.switched.memory.B.cells

B.CELL.rWBC

0.738

< 0.001

0.000

Strong correlation

xcell.DC

DC.rWBC

0.062

0.340

0.370

No or negative correlation

xcell.Eosinophils

EOSINOPHIL.rWBC

0.479

< 0.001

0.000

Moderate correlation

xcell.Memory.B.cells

B.CELL.rWBC

0.731

< 0.001

0.000

Strong correlation

xcell.Monocytes

MONOCYTE.rWBC

0.259

< 0.001

0.000

Weak correlation

xcell.Naive.B.cells

B.CELL.rWBC

0.786

< 0.001

0.000

Strong correlation

xcell.Neutrophils

NEUTROPHIL.rWBC

0.797

< 0.001

0.000

Strong correlation

xcell.NK.cells

NK.rWBC

0.411

< 0.001

0.000

Moderate correlation

xcell.NKT

NKT.rWBC

− 0.252

< 0.001

0.000

No or negative correlation

xcell.pDC

PDC.rWBC

0.086

0.187

0.213

No or negative correlation

xcell.Plasma.cells

PLASMABLAST.rWBC

0.520

< 0.001

0.000

Strong correlation

xcell.Tgd.cells

GAMMA.DELTA.T.rWBC

0.329

< 0.001

0.000

Moderate correlation

xcell.Tregs

TREG.rWBC

0.048

0.461

0.480

No or negative correlation

  1. r > 0.5 = strong correlation, 0.3 < r < 0.5 = moderate correlation, r < 0.3 [false discovery rate (FDR) < 0.1] = weak correlation, and FDR > 0.1 = no correlation. Remaining cell types were not tested due to the lack of the corresponding flow cytometry data.
Back to article page