Table 1 Temporal evolution of hemodynamic characteristics obtained longitudinally in a rabbit model. Cardiac output (CO) from each experimental group was quantified by 2D PC-MRI in the ascending aorta. Measured mean blood pressure (MBP) and pulsatile pressure (PP) from the catheter at final week (TP-4) and estimated at younger ages based on obstruction level % (TP-1, 2, and 3). Additional details related to branch blood flow distributions and pressures are provided in the Supplemental Materials.

From: Temporal evolution of mechanical stimuli from vascular remodeling in response to the severity and duration of aortic coarctation in a preclinical model

Group

TP-1

TP-2

TP-3

TP-4

CO (ml/s)

BP (mmHg)

CO (ml/s)

BP (mmHg)

Obstr %

CO (ml/s)

BP (mmHg)

Obstr %

CO (ml/s)

BP (mmHg)

Obstr %

MBP

PP

Obstr %

MBP

PP

MBP

PP

MBP

PP

Control

2.13

55.7

14.9

0

2.58

55.7

14.9

0

4.76

55.7

14.9

0

6.18

55.7

14.9

0

CoA ≤ 10

2.20

71.5

17.0

69

2.53

71.5

17.2

71

3.97

71.5

18.3

76

5.23

71.5

19.5

80

CoA10-20

1.91

66.7

16.5

63

2.25

66.7

16.9

68

3.98

66.7

22.2

85

5.98

66.7

24.3

87

CoA ≥ 20

2.57

70.2

24.2

87

2.87

70.2

24.9

88

4.64

70.2

28.2

90

6.21

70.2

30.2

92

dCoA ≤ 10

2.47

63.3

16.9

68

2.78

63.3

16.8

67

4.73

63.3

15.9

45

7.02

63.3

15.6

34

dCoA10-20

1.61

65.2

18.8

78

2.07

65.2

18.5

77

4.29

65.2

16.0

50

6.64

65.2

15.7

40

dCoA ≥ 20

2.55

66.4

26.4

89

2.90

66.4

28.8

91

5.00

66.4

20.6

82

6.96

66.4

15.9

47

RdCoA ≤ 10

3.60

60.4

16.0

51

4.14

60.4

15.8

45

6.94

60.4

15.3

19

8.95

60.4

15.0

5

RdCoA10-20

2.44

63.8

16.8

66

3.05

63.8

15.8

44

5.93

63.8

15.3

20

8.19

63.8

15.3

19

RdCoA ≥ 20

2.95

56.9

21.0

83

3.46

56.9

21.8

84

6.32

56.9

15.6

33

8.46

57.0

15.6

33

Back to article page