Table 1 Mendelian randomization of basal metabolic rate (Neale Lab) on father's and mother's attained age (Pilling et al.). CI: confidence interval; GV: genetic variant; IVW: inverse-variance weighting; LL: lower limit; MR: Mendelian randomization; MR-RAPS: Mendelian Randomization Robust Adjusted Profile Score; MR-PRESSO: Mendelian Randomization Pleiotropy Residual Sum and Outlier; SE: standard error; UL: upper limit; WM: weighted median.
From: Effect of basal metabolic rate on lifespan: a sex-specific Mendelian randomization study
Exposure | Outcome | Selection of GVs | No. of GVs | MR method | Beta | Years of life lost | p-value | Cochran's Q | MR-Egger | Outlier detected by MR-PRESSO | Sex difference for years of life lost | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Trait | Sex | Trait | Sex | Estimate | SE | 95% CI LL | 95% CI UL | Estimate | SE | 95% CI LL | 95% CI UL | Statistic | p-value | Intercept | Intercept p-value | I2GX | z statistic | p-value | |||||
Men | |||||||||||||||||||||||
Basal metabolic rate | Men | Father's attained age | Men | All | 178 | IVW (random) | 0.020 | 0.009 | 0.003 | 0.037 | 0.46 | 0.20 | 0.07 | 0.85 | 0.021 | 360.839 | 1.14E−14 | – | – | – | – | 2.894 | 0.004 |
All | 178 | WM | 0.022 | 0.010 | 0.002 | 0.042 | 0.50 | 0.24 | 0.04 | 0.96 | 0.035 | – | – | – | – | – | – | 1.946 | 0.052 | ||||
All | 178 | MR-Egger | 0.004 | 0.023 | –0.041 | 0.049 | 0.10 | 0.52 | –0.93 | 1.12 | 0.855 | 359.698 | 1.07E−14 | 0.001 | 0.455 | 0.826 | – | 1.300 | 0.194 | ||||
All | 178 | MR-RAPS | 0.021 | 0.006 | 0.009 | 0.033 | 0.47 | 0.14 | 0.20 | 0.75 | 0.001 | – | – | – | – | – | – | 4.198 | 2.70E–05 | ||||
All | 175 | MR–PRESSO (corrected) | 0.022 | 0.008 | 0.007 | 0.037 | 0.50 | 0.18 | 0.15 | 0.85 | 0.005 | – | – | – | – | – | rs112875651, rs3184504, rs62396185 | 2.869 | 0.004 | ||||
Exclusion of potentially confounded GVs | 162 | IVW (random) | 0.019 | 0.009 | 0.001 | 0.038 | 0.44 | 0.22 | 0.01 | 0.86 | 0.044 | 327.644 | 1.89E−13 | – | – | – | – | 2.739 | 0.006 | ||||
Exclusion of potentially confounded GVs | 162 | WM | 0.005 | 0.011 | −0.017 | 0.026 | 0.11 | 0.25 | −0.39 | 0.60 | 0.675 | − | − | − | − | − | − | 3.330 | 0.001 | ||||
Exclusion of potentially confounded GVs | 162 | MR-Egger | −0.007 | 0.025 | −0.057 | 0.043 | −0.16 | 0.58 | −1.30 | 0.98 | 0.783 | 325.157 | 2.51E−13 | 0.001 | 0.269 | 0.773 | − | 1.947 | 0.052 | ||||
Exclusion of potentially confounded GVs | 162 | MR-RAPS | 0.020 | 0.007 | 0.007 | 0.033 | 0.45 | 0.15 | 0.15 | 0.75 | 0.003 | – | – | – | – | – | – | 3.930 | 8.49E–05 | ||||
Exclusion of potentially confounded GVs | 159 | MR-PRESSO (corrected) | 0.021 | 0.008 | 0.005 | 0.038 | 0.49 | 0.19 | 0.11 | 0.86 | 0.012 | – | – | – | – | – | rs112875651, rs3184504, rs62396185 | 2.877 | 0.004 | ||||
Women | |||||||||||||||||||||||
Basal metabolic rate | Women | Mother's attained age | Women | All | 180 | IVW (random) | 0.052 | 0.009 | 0.034 | 0.071 | 1.36 | 0.24 | 0.89 | 1.82 | 1.32E–08 | 357.236 | 5.93E–14 | – | – | – | – | ||
All | 180 | WM | 0.048 | 0.011 | 0.025 | 0.070 | 1.23 | 0.30 | 0.65 | 1.82 | 3.32E–05 | – | – | – | – | – | – | ||||||
All | 180 | MR-Egger | 0.046 | 0.026 | –0.004 | 0.096 | 1.19 | 0.66 | –0.10 | 2.49 | 0.071 | 357.092 | 4.31E–14 | 0.0002 | 0.789 | 0.829 | – | ||||||
All | 180 | MR-RAPS | 0.054 | 0.007 | 0.041 | 0.067 | 1.40 | 0.17 | 1.07 | 1.74 | 2.22E–16 | – | – | – | – | – | – | ||||||
All | 177 | MR-PRESSO (corrected) | 0.051 | 0.009 | 0.034 | 0.068 | 1.32 | 0.22 | 0.88 | 1.76 | 1.77E–08 | – | – | – | – | – | rs10774624, rs2102278, rs9843653 | ||||||
Exclusion of potentially confounded GVs | 161 | IVW (random) | 0.052 | 0.010 | 0.033 | 0.072 | 1.35 | 0.26 | 0.85 | 1.86 | 1.34E–07 | 308.741 | 1.62E–11 | – | – | – | – | ||||||
Exclusion of potentially confounded GVs | 161 | WM | 0.056 | 0.012 | 0.032 | 0.081 | 1.46 | 0.32 | 0.84 | 2.08 | 4.40E–06 | – | – | – | – | – | – | ||||||
Exclusion of potentially confounded GVs | 161 | MR-Egger | 0.065 | 0.029 | 0.008 | 0.121 | 1.67 | 0.74 | 0.22 | 3.13 | 0.024 | 308.331 | 1.27E–11 | –0.0004 | 0.645 | 0.771 | – | ||||||
Exclusion of potentially confounded GVs | 161 | MR-RAPS | 0.054 | 0.007 | 0.040 | 0.068 | 1.40 | 0.19 | 1.03 | 1.77 | 7.33E–14 | – | – | – | – | – | – | ||||||
Exclusion of potentially confounded GVs | 159 | MR-PRESSO (corrected) | 0.053 | 0.009 | 0.035 | 0.072 | 1.38 | 0.24 | 0.90 | 1.86 | 6.95E–08 | – | – | – | – | – | rs10774624, rs2102278 | ||||||
