Table 2 Mendelian randomization of basal metabolic rate (Neale Lab) on survival to old age (Deelen et al.). CI: confidence interval; GV: genetic variant; IVW: inverse-variance weighting; LL: lower limit; MR: Mendelian randomization; MR-RAPS: Mendelian Randomization Robust Adjusted Profile Score; MR-PRESSO: Mendelian Randomization Pleiotropy Residual Sum and Outlier; SE: standard error; UL: upper limit; WM: weighted median.

From: Effect of basal metabolic rate on lifespan: a sex-specific Mendelian randomization study

Exposure

Outcome

Selection of GVs

No. of GVs

MR method

Beta

Odds ratio

p-value

Cochran's Q

MR-Egger

Outlier detected

Sex difference

Trait

Sex

Trait

Sex

Estimate

SE

95% CI LL

95% CI UL

Estimate

95% CI LL

95% CI UL

Statistic

p-value

Intercept

Intercept p-value

I2GX

by MR-PRESSO

z statistic

p-value

Men

Basal metabolic rate

Men

Survival to 99th percentile of age

Overall

All

202

IVW (random)

−0.087

0.095

−0.275

0.100

0.916

0.760

1.105

0.359

259.518

0.003

–

–

–

–

0.420

0.674

    

All

202

WM

−0.217

0.136

−0.484

0.050

0.805

0.617

1.051

0.111

–

–

–

–

–

–

1.098

0.272

    

All

202

MR-Egger

−0.339

0.280

−0.888

0.210

0.713

0.412

1.234

0.226

258.342

0.003

0.008

0.340

0.838

–

0.010

0.992

    

All

202

MR-RAPS

−0.089

0.085

−0.256

0.078

0.914

0.774

1.081

0.294

–

–

–

–

–

–

0.474

0.636

    

All

201

MR-PRESSO (corrected)

−0.062

0.093

−0.245

0.122

0.940

0.783

1.130

0.510

–

–

–

–

–

rs768023

0.242

0.809

    

Exclusion of potentially confounded GVs

186

IVW (random)

−0.042

0.102

−0.241

0.158

0.959

0.786

1.172

0.684

231.722

0.011

–

–

–

–

0.785

0.433

    

Exclusion of potentially confounded GVs

186

WM

−0.185

0.145

−0.468

0.099

0.831

0.626

1.104

0.202

–

–

–

–

–

–

1.622

0.105

    

Exclusion of potentially confounded GVs

186

MR-Egger

−0.126

0.315

−0.744

0.491

0.881

0.475

1.634

0.689

231.621

0.010

0.003

0.776

0.791

–

0.461

0.645

    

Exclusion of potentially confounded GVs

186

MR-RAPS

−0.042

0.093

−0.224

0.139

0.958

0.799

1.149

0.646

–

–

–

–

–

–

0.864

0.388

    

Exclusion of potentially confounded GVs

185

MR-PRESSO (corrected)

−0.011

0.099

−0.206

0.185

0.989

0.814

1.203

0.915

–

–

–

–

–

rs768023

0.755

0.450

Basal metabolic rate

Men

Survival to 90th percentile of age

Overall

All

204

IVW (random)

−0.098

0.063

−0.221

0.026

0.907

0.801

1.026

0.120

288.099

7.92E−05

–

–

–

–

0.381

0.704

    

All

204

WM

−0.048

0.086

−0.217

0.122

0.953

0.805

1.129

0.581

-

-

-

-

-

-

0.071

0.943

    

All

204

MR-Egger

−0.313

0.179

−0.665

0.039

0.731

0.514

1.040

0.081

285.783

9.46E−05

0.007

0.201

0.832

-

0.422

0.673

    

All

204

MR-RAPS

−0.100

0.054

−0.205

0.005

0.905

0.814

1.005

0.061

–

–

–

–

–

–

0.442

0.659

    

All

203

MR-PRESSO (corrected)

−0.082

0.062

−0.203

0.040

0.921

0.816

1.040

0.186

–

–

–

–

–

rs768023

0.622

0.534

    

Exclusion of potentially confounded GVs

188

IVW (random)

−0.104

0.068

−0.236

0.029

0.902

0.789

1.030

0.126

262.112

0.0002

–

–

–

–

0.793

0.428

    

Exclusion of potentially confounded GVs

188

WM

−0.010

0.092

−0.189

0.170

0.991

0.828

1.185

0.917

–

–

–

–

–

–

0.491

0.623

    

Exclusion of potentially confounded GVs

188

MR-Egger

−0.305

0.201

−0.699

0.089

0.737

0.497

1.093

0.129

260.522

0.0003

0.006

0.287

0.783

–

1.035

0.301

    

Exclusion of potentially confounded GVs

188

MR-RAPS

−0.106

0.058

−0.220

0.007

0.899

0.802

1.008

0.067

–

–

–

–

–

–

0.934

0.350

    

Exclusion of potentially confounded GVs

187

MR-PRESSO (corrected)

−0.085

0.066

−0.215

0.046

0.919

0.806

1.047

0.201

–

–

–

–

–

rs768023

0.796

0.426

Women

Basal metabolic rate

Women

Survival to 99th percentile of age

Overall

All

202

IVW (random)

−0.029

0.100

−0.225

0.167

0.971

0.798

1.182

0.770

249.285

0.012

–

–

–

–

  
    

All

202

WM

−0.0003

0.143

−0.280

0.280

0.9997

0.756

1.322

0.998

–

–

–

–

–

–

  
    

All

202

MR-Egger

−0.335

0.293

−0.909

0.238

0.715

0.403

1.269

0.252

247.751

0.012

0.009

0.266

0.867

–

  
    

All

202

MR-RAPS

−0.030

0.091

−0.209

0.149

0.971

0.812

1.161

0.743

–

–

–

–

–

–

  
    

All

202

MR-PRESSO*

−0.029

0.100

−0.227

0.168

0.971

0.797

1.183

0.770

–

–

–

–

–

–

  
    

Exclusion of potentially confounded GVs

183

IVW (random)

0.074

0.107

−0.136

0.284

1.077

0.873

1.329

0.490

218.214

0.034

–

–

–

–

  
    

Exclusion of potentially confounded GVs

183

WM

0.157

0.153

−0.143

0.457

1.170

0.867

1.579

0.305

–

–

–

–

–

–

  
    

Exclusion of potentially confounded GVs

183

MR-Egger

0.087

0.338

−0.575

0.749

1.091

0.563

2.114

0.797

218.212

0.031

–0.0004

0.968

0.836

–

  
    

Exclusion of potentially confounded GVs

183

MR-RAPS

0.076

0.100

−0.120

0.271

1.079

0.887

1.311

0.447

–

–

–

–

–

–

  
    

Exclusion of potentially confounded GVs

182

MR-PRESSO (corrected)

0.098

0.105

−0.109

0.305

1.103

0.896

1.356

0.353

–

–

–

–

–

rs599004

  

Basal metabolic rate

Women

Survival to 90th percentile of age

Overall

All

203

IVW (random)

−0.063

0.067

−0.194

0.067

0.939

0.824

1.070

0.343

277.242

0.0003

–

–

–

–

  
    

All

203

WM

−0.057

0.093

−0.239

0.126

0.945

0.787

1.134

0.542

–

–

–

–

–

–

  
    

All

203

MR-Egger

−0.202

0.193

−0.580

0.177

0.817

0.560

1.194

0.297

276.441

0.0003

0.004

0.446

0.851

–

  
    

All

203

MR-RAPS

−0.065

0.058

−0.178

0.048

0.937

0.837

1.050

0.262

–

–

–

–

–

–

  
    

All

201

MR-PRESSO (corrected)

−0.027

0.063

−0.152

0.098

0.974

0.859

1.103

0.673

–

–

–

–

–

rs3800228, rs599004

  
    

Exclusion of potentially confounded GVs

184

IVW (random)

−0.026

0.071

−0.164

0.113

0.974

0.848

1.119

0.714

237.752

0.004

–

–

–

–

  
    

Exclusion of potentially confounded GVs

184

WM

0.056

0.098

−0.136

0.248

1.058

0.873

1.281

0.568

–

–

–

–

–

–

  
    

Exclusion of potentially confounded GVs

184

MR-Egger

0.002

0.218

−0.426

0.430

1.002

0.653

1.537

0.994

237.728

0.003

–0.0008

0.894

0.812

–

  
    

Exclusion of potentially confounded GVs

184

MR-RAPS

−0.026

0.063

−0.150

0.097

0.974

0.861

1.102

0.674

–

–

–

–

–

–

  
    

Exclusion of potentially confounded GVs

183

MR-PRESSO (corrected)

−0.009

0.069

−0.145

0.126

0.991

0.865

1.135

0.895

–

–

–

–

–

rs599004

  
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