Table 2 The EC50 values on apElevRs by elevenin analogs with alanine substitutions. Analogs are ordered based on the conserveness of each residue (Fig. 1).

From: Identification of three elevenin receptors and roles of elevenin disulfide bond and residues in receptor activation in Aplysia californica

Conserved residues

apElevR1

apElevR3

apElevR2

Elevenin

25

3.1

1.2

[Ala17]Elevenin

8200

5100

> 10,000

[Ala16]Elevenin

130

2000

> 10,000

[Ala13]Elevenin

120

380

> 10,000

[Ala5]Elevenin

48

440

> 10,000

[Ala11]Elevenin

110

280

240

[Ala18]Elevenin

26

14

NA

[Ala4]Elevenin

39

26

NA

  1. Analogs with substituted residues inside the disulfide bond were highlighted in italic.
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