Figure 3
From: KCC2 downregulation after sciatic nerve injury enhances motor function recovery
Preventing injury-induced KCC2 downregulation impairs post-injury recovery of motor function. (A,B) Motor performance scores (rpm at falling), measured before (pre), and at 1, 3, 7, 14, 21, 28, 35 and 42-days after SNC or sham-SNC, for wild-type and CaMKII-KCC2 mice. Cohort means and standard deviations are plotted. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; 2-way repeated measures ANOVA, post hoc Bonferroni multiple comparisons test for pre vs [1, 3, 7, 14, 21, 28, 35, 42]-days post-SNC per each cohort. Cohorts [wild-type, CaMKII-KCC2]. (A) Sham-SNC, n = [6, 6] mice. (B) SNC, n = [10, 11] mice. (C,D) Degree of motor function recovery ([day-42/pre] rpm × 100%) after SNC or sham-SNC, for wild-type and CaMKII-KCC2 mice. Each data point represents one mouse. Columns indicate cohort medians. *p < 0.05, **p < 0.01; Mann Whitney test. Cohorts as in (A,B), respectively. (C) Sham-SNC. (D) SNC.
