Figure 5 | Scientific Reports

Figure 5

From: Extracellular vesicles of trypomastigotes of Trypanosoma cruzi induce changes in ubiquitin-related processes, cell-signaling pathways and apoptosis

Figure 5

“Protective” effect of extracellular vesicles of trypomastigotes of T. cruzi over apoptosis of Vero cells. (A) Significant lower relative values of cells in early and late apoptosis were observed in cells incubated with EV and then treated with taxol for 72 h. The values are represented as the mean percentages ± SEM. Tukey–Kramer test, where *** p < 0.001; **** p < 0.0001 and ns: non-significant differences. mRNA expression levels (B) and Western blot analysis (C) of casein kinase protein CSNK1G1 that shows an increase in protein synthesis after the interaction of cells with EV of the parasite. Expression was calculated as fold induction caused by the respective treatment/control as compared with the expression of GAPDH. Data are presented as shown above, with mean ± S.D. (n = 3). Differences to this value were analyzed by one sample Wilcoxon signed rank tests (asterisks), where * p < 0.05.

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