Figure 7

Signal intensity and tubeness distributions. (a) Signal intensity from the brains with contrast agent (Rat 1–5) and without contrast agent (Naïve 1–2). The signal intensity for each animal was mapped linearly between 0 and 1. (b) Signal intensity following intensity range remapping to align signal distribution peaks and create better perivascular contrast with the surrounding tissue. (c–d) Tubeness distribution for the brain (c) interior and (d) surface. The gray vertical line is the average of the tubeness values corresponding to the 0.95 cumulative distribution value in each naïve brain. This tubeness value is greater than the tubeness in 95% of the naïve voxels on average.