Figure 1
From: Indel driven rapid evolution of core nuclear pore protein gene promoters
Positive selection drives the evolution of the nuclear pore complex proteins. (a) Graphic depiction of the nuclear pore complex with differentially coloured subcomplexes inner ring (IR, pink), outer ring (OR, blue), cytoplasmic filament (CF, orange), nuclear basket (purple) and pore membrane proteins (POMS, red) embedded in the nuclear envelope lipid-bilayer (green). (b) Significance of synonymous to non-synonymous changes in Nup subcomplex open reading frames (ORFs) indicated by an asterisk and p values. (c) Average proportion of substitutions fixed by positive selection (α) shown with standard deviation. 30 genes were randomly sampled 100 times with replacements from the list of Nups and from the genome. Statistically significant differences from unpaired student t tests are indicated by asterisks (*** p ≤ 0.0001). (d–f) Significance of synonymous to non-synonymous changes in ORFs indicated by an asterisk and p values. As positive control groups the "best candidate genes" under balancing selection for European (d) and African (e) populations were used. As a negative control group, the highly conserved m6A writer complex and m6A readers were analysed (f).
