Table 1 Clinical features of young and middle-aged Japanese women.

From: Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in women

OGTT

Young

Middle-aged

p values

n = 307

n = 148

n = 118

n = 65

Age (years)

20.5 ± 1.2

49.8 ± 3.6

 < 0.001

BMI (kg/m2)

20.4 ± 2.2

22.0 ± 2.8

 < 0.001

Waist (cm)

71.2 ± 5.7

78.7 ± 8.1

 < 0.001

Percentage body fat (%)

27.8 ± 5.5

30.1 ± 7.3

0.001

Percentage trunk fat (%)

28.6 ± 6.6

32.9 ± 8.7

 < 0.001

Fasting glucose (mg/dL)

83 ± 7

89 ± 14

 < 0.001

30-min glucose (mg/dL)

122 ± 23

138 ± 31

 < 0.001

1-h glucose(mg/dL)

104 ± 33

133 ± 42

 < 0.001

2-h glucose (mg/dL)

94 ± 23

113 ± 28

 < 0.001

Fasting insulin (μU/mL)

6.2 ± 3.4

5.4 ± 2.8

0.014

30-min insulin (μU/mL)

54 ± 34

39 ± 24

0.001

1-h insulin (μU/mL)

44 ± 27

42 ± 24

0.678

2-h insulin (μU/mL)

42 ± 25

37 ± 29

0.239

HbA1c (%)

5.2 ± 0.2

5.5 ± 0.4

 < 0.001

HOMA-IR

1.28 ± .78

1.21 ± .71

0.354

IGI

3.8 ± 11.8

1.0 ± 1.0

0.012

Oral disposition index

39 ± 129

9 ± 10

0.015

Matsuda index

9.1 ± 4.2

9.5 ± 4.6

0.505

AUCg (mg/dL/2 h)

207 ± 42

248 ± 56

 < 0.001

AUCi (μU/mL/2 h)

82 ± 39

71 ± 38

0.064

AST (U/L)

17 ± 5

21 ± 13

0.001

ALT (U/L)

13 ± 7

20 ± 18

 < 0.001

ALT/AST

0.74 ± 0.24

0.91 ± 0.26

 < 0.001

Orosomucoid (mg/dL)

125 ± 26

148 ± 35

 < 0.001

hsCRP (μg/dL)

29 ± 69

17 ± 54

0.067

  1. Mean ± SD. HOMA-IR: homeostasis model assessment-insulin resistance. IGI: insulinogenic index, AUCg and AUCi: area under the glucose and insulin concentration curve, respectively, AST and ALT: aspartate- and alanine-aminotransferase, respectively, hsCRP: high-sensitivity C-reactive protein.
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