Table 2 Incidence rate of pneumonia.

Pneumonia	Unmatched population				Propensity score-matched population
Pneumonia	All	LAMA	ICS/LABA	p-value	All	LAMA	ICS/LABA	p-value
Incidence rate per 1000 PYs	102.78	90.20	147.09	< 0.001	112.41	93.96	136.42	< 0.001
Patients with event	812	555	257		366	173	193
Sum of PYs	7900.29	6153.06	1747.23		3256.03	1841.3	1414.73
Time to event
Mean	432.61	446.42	402.79		441.61	523.64	368.08
SD	548.35	563.61	513.63		568.5	675.18	441.04
Median	257.5	256	265		265.5	280	259
Min	2	2	2		2	2	2
Max	3481	3481	2995		3481	3481	2791
P25	96	96	93		103	112	98
P75	495	525	471		514	604	437
Age (years)
55 to < 75	90.35	77.90	136.62	< 0.001	100.45	82.37	125.05	0.002
75+	137.84	126.49	172.47	0.018	143.86	126.66	163.82	0.144
Sex
Male	100.99	89.96	146.01	< 0.001	114.73	97.85	136.73	0.005
Female	111.66	91.67	150.17	0.003	104.59	80.80	135.40	0.023
History of COPD exacerbation
None	95.27	82.78	139.34	< 0.001	105.25	88.78	126.5	0.003
1 moderate	140.57	122.65	214.09	0.045	142.28	84.91	220.8	0.012
≥ 2 moderate OR ≥ 1 severe	149.54	140.35	178.36	0.277	149.82	137.98	165.74	0.506

LAMA long-acting muscarinic antagonists, ICS inhaled corticosteroid, LABA long-acting β2-agonists, PYs Person years, SD standard deviation, COPD Chronic obstructive pulmonary disease.

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