Figure 1 | Scientific Reports

Figure 1

From: Noradrenergic stimulation of α1 adrenoceptors in the medial prefrontal cortex mediates acute stress-induced facilitation of seizures in mice

Figure 1

Noradrenaline (NA) promotes the induction of epileptiform activity (EA) in layer 5 pyramidal cells of the medial prefrontal cortex under the suppression of inhibitory synaptic transmission. (a) Representative micrograph of a recorded pyramidal cell. (b) Representative traces showing the effects of picrotoxin (Pic) on evoked inhibitory postsynaptic currents (eIPSCs). (c) Summary graph showing the effects of Pic on eIPSCs (n = 5 from 4 mice). **P < 0.01 (one-way ANOVA with post hoc Holm–Sidak’s test). (d, f) Representative traces of membrane potentials after the application of Pic (d) and Pic + NA (f). (e, g, h, i) Expanded traces of a mark in d (e), marks at short (g) and long (i) times after the application of NA in f, and a mark in g (h). (j, k) Summary graphs of EA latency (j) and number of EAs (k) after the application of Pic (n = 6 from 4 mice) or Pic + NA (n = 7 from 7 mice). (l, m) Summary graphs of changes in duration (l) and number of burst firings (m) in EAs after the application of NA (n = 6 from 6 mice). *P < 0.05, **P < 0.01, ****P < 0.0001 (Student’s t-test or paired t-test). Data are expressed as mean ± standard error of the mean.

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