Figure 7 | Scientific Reports

Figure 7

From: Noradrenergic stimulation of α1 adrenoceptors in the medial prefrontal cortex mediates acute stress-induced facilitation of seizures in mice

Figure 7

Restraint stress (RS) promotes the induction of seizures by stimulating α1 adrenoceptors in vivo. (a) Experimental timeline and placements of the infusion cannula tips: picrotoxin + restraint stress + vehicle (Pic + RS + Veh, red circles, n = 9) and picrotoxin + restraint stress + terazosin (Pic + RS + Ter, blue circles, n = 7). Numbers indicate the approximate anterior–posterior distance (mm) from the bregma. (b) Latency of stage 3 seizures. Data are expressed as mean ± standard error of the mean. *P < 0.05, #P < 0.05 (two-way repeated measures ANOVA with post hoc Bonferroni's test). NS, not significant.

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