Figure 8
PS18 suppressed the expression of ER stress markers in nigra. (A–D) 6-OHDA significantly upregulated the expression of PERK, ATF6, CHOP, and BiP mRNA in the lesioned nigra, examined by qRTPCR. PS18 significantly attenuated the expression of (A) PERK, (C) BiP, and (D) CHOP. (E, F) Another set of animals were used for Western blot analysis. (E) Representing Western blots. (B) Administration of 6-OHDA significantly increased BiP protein level in the lesioned nigra (non-lesioned vs. 6-OHDA). PS18 antagonized 6-OHDA-induced BiP expression (p < 0.05, one-way ANOVA + NK test).
