Table 2 Imaging features recorded at baseline.

From: Angiographic biomarkers are significant predictors of treatment response to intravitreal aflibercept in diabetic macular edema

Imaging features

No. (%)

Presence of exudates

34 (44.7)

Microaneurysms

 No microaneurysms

2 (2.6)

 < 10 microaneurysms

26 (33.3)

 > 10 microaneurysms

48 (63.2)

Macula fluorescein leakage pattern

 Focal

22 (29.3)

 Intermediate

20 (26.7)

 Diffuse

33 (44.0)

 Non-perfusion outside ETDRS 7-field grid on UWF FA

33 (46.5)

OCT features

 Presence of Subretinal Fluid

17 (22.7)

 Cystoid changes in the INL

51 (68.0)

 Cystoid changes in the ONL

71 (95.9)

 Presence of DRiL

19 (25.7)

 Intact ELM and EZ

62 (83.8)

 Presence of intraretinal HRF

59 (79.7)

OCTA features

 Intact terminal foveal capillary ring

20 (26.7)

 Perifoveal capillary loss

62 (82.7)

 Foveal avascular zone

 Area, perimeter, diameter, axis ratio, eccentricity, acircularity

 Macular vessel density

  1. DRiL  Disorganization of Retinal inner Layers; ELM = External Limiting Membrane; ETDRS   Early Treatment Diabetic Retinopathy Study; EZ  Ellipsoid Zone; HRF Hyperreflective Foci; INL Inner Nuclear Layer; OCT Optical Coherence Tomography; OCTA  Optical Coherence Tomography Angiography; ONL Outer Nuclear Layer; UWF FA   Ultra Widefield Fluorescein Angiography.