Figure 5 | Scientific Reports

Figure 5

From: Insulin-like growth factor binding protein-3 induces senescence by inhibiting telomerase activity in MCF-7 breast cancer cells

Figure 5

IGFBP-3 decreases telomerase activity independent of caspase-mediated apoptosis. Relative quantification of telomerase activity levels after the induction of IGFBP-3 in the presence or absence of pan-caspase inhibitor (z-VAD-fmk), siRNA:IGFBP-3, or scrambled siRNA. Induction of IGFBP-3 decreased telomerase activity. The effect of IGFBP-3 on telomerase activity was prevented by co-treatment with siRNA:IGFBP-3, but not abolished by the pan-caspase inhibitor or scrambled siRNA. a. p < 0.05, vs. ponasterone A-untreated cells; b. p < 0.05, vs. ponasterone A-treated cells. Multiple comparisons were performed using one-way ANOVA with Bonferroni post-hoc analysis. Each bar represents the mean ± SD of three independent experiments.

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